Publications & Patents

Types of Synthetic & Semi-Synthetic Reactions

Below are links to peer-reviewed journal articles that have been authored by our scientists and published in well-respected scientific journals as well as links to patents and patent applications surrounding a variety of synthetic and semi-synthetic reactions.

*Click on any of the publication or patent titles to review the abstract and access a link to the full text.

Agricultural Formulation Chemistry

• Method for Providing a Stable Protective Coating for UV Sensitive Pesticides. (US 5,939,089) Kevin Wirtz, Ph.D.

Alkyl Lithium Chemistry

• An Improved Method For the Synthesis of Substituted Cyclobutenediones. Kevin Wirtz, Ph.D.

Aromatic Oxidation

• Production of Oxidized Humic Acids by an Oxygen-Alkali Process. (US 5,688,999) Kevin Wirtz, Ph.D.

Asymmetric Epoxidation Reaction

• Asymmetric cis - Hydroxylation via Epoxidation-Carboxylation: A Formal Synthesis of (+)-Citreoviral John Lynch, Ph.D.

Asymmetric Protonation

• Asymmetric Proton Catalysis. Jeff McGilvra, Ph.D.

Asymmetric Synthesis

• Syntheses of Colombiasin A and Elisapterosin B John Lynch, Ph.D.
• Recent Syntheses of (+)-Brefeldin A John Lynch, Ph.D.
• Asymmetric Dipolar Cycloaddition Reactions: a Practical, Convergent Synthesis of Chiral Pyrrolidines John Lynch, Ph.D.
• Asymmetric cis - Hydroxylation via Epoxidation-Carboxylation: A Formal Synthesis of (+)-Citreoviral John Lynch, Ph.D.
• Enantioselective Synthesis of Cryptocarya Triacetate, Cryptocaryolone and Cryptocaryolone Diacetate Catherine Smith, Ph.D.
• Facial Selectivity of the Sharpless Bromine Catalyzed Aziridination Reaction. Catherine Smith, Ph.D.
• Carbon-substituted Co(III) Salens as Effective Catalysts for Enantioselective Diels-Alder Reactions. Jeff McGilvra, Ph.D.
• Highly Enantio- and Diastereoselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding. Jeff McGilvra, Ph.D.
• Asymmetric Proton Catalysis. Jeff McGilvra, Ph.D.

Diels-Alder Reaction

• Carbon-substituted Co(III) Salens as Effective Catalysts for Enantioselective Diels-Alder Reactions. Jeff McGilvra, Ph.D.

Dipolar Cycloaddition Reaction

• Asymmetric Dipolar Cycloaddition Reactions: a Practical, Convergent Synthesis of Chiral Pyrrolidines John Lynch, Ph.D.

Functionalization of Strained Cyclic Ketones

• An Improved Method For the Synthesis of Substituted Cyclobutenediones. Kevin Wirtz, Ph.D.

Halogenation

• Development of a Commercial Process to Produce Oxandrolone. John Cabaj & Tom Benson
• An Effective Method for the Preparation of 21-Chlorosteroids Using the Vilsmeier Reagent. John Cabaj

Heteroaromatic Palladium Coupling Reactions

• Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721. Jonathan Pease, Ph.D.

Hydroquinone Synthesis

• Synthesis of (.eta.4-1,4-naphthoquinone)(.eta.5-pentamethylcyclopentadienyl)cobalt complexes. Kevin Wirtz, Ph.D.

Intramolecular Hoesch Reaction

• Benzocycloheptene Devrivatives from the Hoesch Reaction. Jonathan Pease, Ph.D.

Large Scale Epoxidation

• Large-Scale Preparation of (+)-p-Menth-2-ene-1,8-diol, a Key Intermediate in the Synthesis of delta-9-Tetrahydrocannibol. John Cabaj

Large Scale Ozonolysis Reaction

• Development of a Commercial Process to Produce Oxandrolone. John Cabaj & Tom Benson

Metathesis Reaction

• Enantioselective Synthesis of Cryptocarya Triacetate, Cryptocaryolone and Cryptocaryolone Diacetate Catherine Smith, Ph.D.

Mukaiyama Reaction

• Highly Enantio- and Diastereoselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding. Jeff McGilvra, Ph.D.

Organocatalysis

• Highly Enantio- and Diastereoselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding. Jeff McGilvra, Ph.D.
• Asymmetric Proton Catalysis. Jeff McGilvra, Ph.D.

Organometallic Chemistry

• Synthesis of (.eta.4-1,4-naphthoquinone)(.eta.5-pentamethylcyclopentadienyl)cobalt complexes. Kevin Wirtz, Ph.D.

Polymer Chemistry

• Method for Providing a Stable Protective Coating for UV Sensitive Pesticides. (US 5,939,089) Kevin Wirtz, Ph.D.

Precursors for Quinone Synthesis

• Synthesis of Regiospecifically Prepared Cyclobutenedione Monoketals. Kevin Wirtz, Ph.D.

• An Improved Method For the Synthesis of Substituted Cyclobutenediones. Kevin Wirtz, Ph.D.

Reductive Annimations

• Process to Prepare Tolterodine. John Cabaj

Sharpless Dihydroxylation Reaction

• Enantioselective Synthesis of Cryptocarya Triacetate, Cryptocaryolone and Cryptocaryolone Diacetate Catherine Smith, Ph.D.

Wittig Reaction

• Wittig Ethylidenation of Ketones:  Reagent Control of Z/E Selectivity. John Cabaj