Paul M. Zizelman

Director of Scientific Operations

Paul oversees all scientific operations for Cedarburg Hauser Pharmaceuticals. As the technical advisor in the project management group, he ensures that potential projects are a good fit with the experience and resources available.  Paul is also responsible for ensuring specific project goals are defined and realized in within the timelines agreed upon.

Paul's 20+ years of experience allow him to anticipate and often prevent situations which could cause delays in development, manufacturing, and quality.

Past Experience

• Manufactured advanced intermediates for pharmaceutical companies
• Manufactured fine chemicals for research and industry.
• Cedar Creek Custom Synthesis ultimately merged with Cedarburg Pharmaceuticals in 2005 and its 3200 sq. ft. facility in Milwaukee, Wisoconsin is currently staffed and used to conduct development activities for Cedarburg Hauser Pharmaceuticals.

• Managed process development projects in the R&D group, which included solving technical problems, researching new routes of synthesis and coordinating activities to meet the project timelines.
• Organized the development of analytical methods with Quality Control and communicated the progress of projects to the Management Team.
• Assisted with evaluation of technical feasibility for new projects.

• New product development and glassware production group.
• Identified new product targets and spearheaded the development of > 500 new products which generate approximately 2.5 million dollars in sales annually.
• Developed an economical route to produce 3,3-dimethylbutyraldehyde, resulting in 2 million dollars in sales. 
• Developed a scaleable route to produce 100 kg batches of water soluble triphenylphosphine.

Education

The ligand substitution kinetics of a series of carbonylmanganese cations MeCpMn(CO)₂L⁺ with L = 3- and 4-substituted pyridine ligands are measured for a variety of phosphine nucleophiles N of deffering steric and electronic properties.  The unified free energy relationship in eq 17 is shown for the first time to accommodate all the extensive rate data, if the steric effect is evaluated by Tolman’s cone angles for the phosphines, and the electronic effects are evaluated by the acid-base dissociation consultants of the pyridine ligands and the phosphine nucleophiles.  The range of the second-order rate constants k₁ for ligand substitution of MeCpMn(CO)₂L+ extends over four decades from 3.0 to 2 X 10⁴ M^-1 s^-1.

This strong dependence of log k₁ on both the electronic and steric effects of the pyridine ligand L and the phosphine nucleophile N points to the associative S_N2 mechanism for the ligand substitution.  The measurement of the fast rates of ligand substitution by transient electrochemical techniques is based on the novel electrocatalysis of the neutral precursor MeCpMn(CO)₂L in the presence of added phosphine nucleophiles, as described in Scheme I.  

The analysis of the electrochemical kinetics for this mechanism by Feldberg’s method for the computer simulation of the cyclic voltammograms and by Saveant’s adimensional evaluation of the CV peak currents is described in detail.