Tom Benson

Chemist

Tom's primary role as a Chemist at Cedarburg Hauser Pharmaceuticals involves developing processes for scaling and manufacturing active pharmaceutical ingredients (API) for our clients. Tom specializes in the synthesis and process development of opioid analgesics, steroids, retinoids, and other phase I-III API’s.

Past Experience | Education | Publications

Past Experience

Aldrich Chemical Company

Chemist

Types of Projects:

Custom Synthesis and new product development of organo-silicon, tin, phosphine, boron reagents, and nucleosides

Education

University of Wisconsin - Madison

B.S. Chemistry, 1985

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Publications

Summary List of Publications

Click on any of the titles below to view the abstract, detailed listing and a link to the complete text on the site which owns the copyright for the article. You may be required to have a membership for the site you are linked to in order to see the complete text.

Development of a Commercial Process to Produce Oxandrolone

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Development of a Commercial Process to Produce Oxandrolone

Organic Process Research and Development (April 20, 2007)

Abstract:

A manufacturing scale process for the preparation of the anabolic steroid Oxandrolone was developed. Key elements include: the bromination of methylandrostanolone with perbromide to give the 2-bromoketone in ca. 80% yield with minimal dehydration, subsequent elimination of the bromide with Li2CO3/LiBr to give the 2-enone in ca. 70% yield with minimal formation of methyltestosterone, and an ozonolysis procedure to give the penultimate intermediate in ca. 90% yield. The overall yield from methylandrostanolone to Oxandrolone using the described process was 45% as compared to the original Searle yield of 8%.

Detailed Listing:

“Development of a Commercial Process to Produce Oxandrolone.” Cabaj, J. E.; Kairys, D.; Benson, T. R. Org. Process Res. Dev. 2007, 11, 378.

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Summary List of Publications | Top