Rafail Usatinsky
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Analytical Services Manager
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As Analytical Services Manager for Cedarburg Hauser Pharmaceuticals, Rafail directs all analytical method development, validation, and technical transfers that supports product development. He specializes in the development of analytical procedures for analysis of small molecules including opioids, vitamin D derivatives, isoquinolines, steroids, prostaglandins, and others.
Rafail provides his technical expertise for impurity identification and analytical testing in support of CMC section for IND, ANDA, and DMF submission. Rafail also monitors and evaluates the scientific performance of assays from product development to release and stability studies.
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Past Experience | Education | Publications | Patents
Past Experience
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| PPD Development |
Analytical Services Manager
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| Types of Projects: |
- Analysis of drug products from stability program.
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| Fugent |
| Analytical Chemist |
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| Types of Projects: |
- Synthesis of novel cationic lipids for gene delivery.
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Education
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| Nizhny Novgorod State University, Russia |
| Ph.D., 1997 |
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| Scientific Advisor: Professor V. Dodonov |
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| Description of important work: |
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Design and development of oxidative synthesis of antimony (V) alkyl and aryl derivatives.
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| Cardinal Stritch University |
MBA, 2003
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| Description of important work: |
- Research of different types of client agreements between pharmaceutical contract research organizations and its sponsors
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Publications
Summary List of Publications
Click on any of the titles below to view the abstract, detailed listing and a link to the complete text on the site which owns the copyright for the article. You may be required to have a membership for the site you are linked to in order to see the complete text.
| The one-stage synthesis and crystal structure of 5,5,5-Trifluoro-2-pentanone-4,4-diolato-triphenylantimony(V) |
View Abstract |
| Reactions of methyl antimony (III, V) derivatives with aliphatic alcohols in the presence of copper (II) |
View Abstract |
| Synthesis of antimony (V) derivatives from trimethyl and triphenylantimony (III), dihydric phenols and tert-butyl hydroperoxide. |
View Abstract |
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| The one-stage synthesis and crystal structure of 5,5,5-Trifluoro-2-pentanone-4,4-diolato-triphenylantimony(V) |
Main Group Chemistry (May, 1998)
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| Abstract: |
| 5,5,5-Trifluoro-2-pentanone-4,4-diolato-triphenylantimony(V) (1) was obtained by the onestep oxidation reaction of triphenylantimony, tert-butylhydroperoxido, and trifluoroacetylacetone. The crystal structure of 1 has been determined by X-ray diffraction method (MoK agr-radiation, graphite monochromator, ?/20-scan mode in the range 2° = 2? = 54°, 3734 observed reflection with F > 6 s (F), R = 0.029, Rw = 0.031, S = 1.03). Crystal of 1 is monoclinic, at 20 C a = 9.369(5) Aring, b = 16.891(6) Aring, c = 13.934(5) Aring, ß = 102.04(2), V = 2157(3) Aring3, d(calcd) = 1.611 g cm-3, Z = 4, space group P21/n. It was shown that 1 is a six-coordinated antimony complex. The coordination mode of the Sb atom in 1 can be described as a significantly distorted octahedron. In crystal structure the molecules of 1 are associated into a centro-symmetrical dimer by a weak hydrogen O…H-C bonds between adjacent molecules. |
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| Detailed Listing: |
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"The one-stage synthesis and crystal structure of 5,5,5-Trifluoro-2-pentanone-4,4-diolato-triphenylantimony(V)." Gushchina, Aleksey V.; Usyatinskya, Rafail I.; Fukinb, Georgy K.; Dodonova, Victor A.; Zakharovb, Lev N. Main Group Chemistry, Volume 2, Issue 3 May 1998 , pages 187 - 190.
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Summary List of Publications | Top
| Reactions of methyl antimony (III, V) derivatives with aliphatic alcohols in the presence of copper (II). |
| Zhurnal Obshchaya Khimiya (Russian Journal of General Chemistry) (1996) |
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| Abstract: |
| Trimethylantimony and copper diacetate (or copper dipelargonate) in a 1: 2 molar ratio substitute the hydrogen atom of the hydroxy group in aliphatic alcohols to form methyl alkyl ethers (yield up to 46%). The activity of alcohols toward methylation depends on the structure of the organic radical of the alcohol. Reactions of trimethylantimony diacetate or dibenzoate with alcohols in the presence of catalytic amounts of copper yield methyl alkyl ethers in 10312% yields. |
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| Detailed Listing: |
| “Reactions of methyl antimony (III, V) derivatives with aliphatic alcohols in the presence of copper (II).” Usyatinskii, R. I.; Gushchin, A. V.; Dodonov, V. A. Zhurnal Obshchaya Khimiya. 1996 pp 1137-1140. |
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| Synthesis of antimony (V) derivatives from trimethyl and triphenylantimony (III), dihydric phenols and tert-butyl hydroperoxide. |
| Russian Chemical Bulletin (April, 1995) |
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| Abstract: |
| Trimethyl and triphenylantimonyo-phenylene dioxides were obtained by the reaction of trimethyl- and triphenylantimony with pyrocatechol in the presence oftert-butyl hydroperoxide in 68 and 81 % yields, respectively. 7,7,7,15,15,15-Hexamethyl-(and phenyl)-6,8,14,16-tetraoxa-7, 15-distibatricyclo[11.3.1.19,13]octadeca-1,3,5,9,11,13-hexaenes were synthesized analogously by the reaction with resorcinol (in 79 and 93 % yields, respectively). The use of hydroquinone resulted in polymeric trimethyl- and triphenylantimony hydroquinolates. |
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| Detailed Listing: |
| "Synthesis of antimony (V) derivatives from trimethyl and triphenylantimony (III), dihydric phenols and tert-butyl hydroperoxide." Dodonov V.A., Usatinsky R.I., Fedorov A.Y., Zaburdyaeva S.N., Gushin A.V. Russian Chemical Bulletin, Volume 44, Number 4 / April, 1995, pp 730-733. |
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Summary List of Publications | Top
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