Taxane Expertise for Cancer Therapeutic Drug Development
If you are working on a taxane based development project, make sure you are working with an API development company that has the experience and expertise you need to be successful. Put our expertise with taxanes to work for your projectCedarburg Hauser Pharmaceuticals is an experienced, contract development and manufacturing company for active pharmaceutical ingredients (API) and pharmaceutical intermediates. We have unique capbilities and superior expertise in the areas of natural product extraction, isolation and purification. We can use our experience and expertise with taxanes to help your cancer therapeutic drug development project be a success. In fact, Hauser Chemical Research, Inc., now part of Cedarburg Hauser Pharmaceuticals, was awarded the first contracts by the National Cancer Institute in the late 1980’s to produce paclitaxel (originally called Taxol, which is now a BMS tradename) from natural sources. We can also make many analogs of paclitaxel for research as well as clinical trials. Contact us today to discuss your specific needs.
Patents for chemical processes to make natural & semi-synthetic paclitaxel under GMPAs a result of our extensive knowledge of taxanes, we have streamlined the chemical processes to make both natural and semi-synthetic paclitaxel under GMP. In fact, our scientists were the inventors on several key patents on these processes. 7-hexanoyltaxol and methods for preparing the same.United States Patent 6,136,988 (October 24, 2000) Process for removing impurities from natural product extracts. United States Patent 6,132,726 (October 17, 2000) Abstract: In general the present invention relates to a process for the removal of undesireable compounds or residues from an extract which are more polar or less polar than the desired target compound. The preferred embodiment of the present invention is a three step process and is described in detail below. The first step includes contacting a plant material that contains the desired target compound(s) with a solvent, thus producing a crude extract containing a mixture of compounds that includes, in addition to the undesireable residues, the desired target compound(s). The second step involves passing the crude extract through a series of columns containing an absorbent that retards the movement of the undesireable compounds, while allowing the desired compounds to pass. The third and final step involves drying the eluant product to achieve a final product. Detailed Listing: "Process for removing impurities from natural product extracts." Daughenbaugh, Randall J.; Bailey, David T.; Gamble, William R.; Gertenbach, Dennis D. United States Patent 6,132,726 (October 17, 2000). Use us for research, development services, and cGMP manufacturingCedarburg Hauser Pharmaceuticals is an experienced, contract development and manufacturing company for active pharmaceutical ingredients (API) and pharmaceutical intermediates. Working with us allows you to combine the benefits of working with a contract research organization (CRO) and a contract manufacturing organization throughout your project. We can apply our expertise in process development and optimization to making your drug candidate, from preclinical evaluation through human trials, all the way to the market place. Cedarburg Hauser Pharmaceuticals as your contract research organization and pharmaceutical services resourceProcess development & scale-up services Our process development chemists will ensure your active pharmaceutical ingredient (API) can be successfully scaled up to the quantities you require for toxicity trials, clinical trials and even into commercialization. Analytical method development services We offer you a comprehensive suite of analytical services to ensure your active pharmaceutical ingredient has the levels of purity and stability you require throughout the various stages of your drug development project. CMC & regulatory services Our regulatory systems have met the rigors and challenges of clinical trials and marketed drugs in several countries. If you need assistance with preparing and submitting your CMC filings or FDA filings, we have the knowledge and experience it takes to efficiently guide you through the complexities of the submission process. Cedarburg Hauser Pharmaceuticals as your contract manufacturing organizationWe have the flexibility to assist you with your GMP and/or non-GMP manufacturing needs for your active pharmaceutical ingredient (API) or pharmaceutical intermediate requirements. You can realize several benefits.
If you need a company that has the experience and proven success with taxanes, paclitaxel and paclitaxel analogs, you can feel confident in trusting Cedarburg Hauser Pharmaceueticals to get the job done. How can we help you with your project?We would love to learn more about your project and explore how we can use our experience and expertise in drug development to help you achieve the successful outcome your are looking for. Contact us today by submitting a request for more information form, a request for quote form, or calling one of our experienced project managers at (262) 376-1467. Allow our experts to ensure your success in developing your cancer therapeutic drug candidate! |
Taxanes such as Paclitaxel and Docetaxel are among the world’s largest selling and best known anticancer drugs. The therapuetic qualities of these diterpine alkaloids that are produced by plants of the genus Taxus continue to be a popular compound for cancer drug development scientists to target.