Retinoid Synthesis and Manufacturing

Retinoids are chemical compounds that are derived from vitamin A, and play a role in diverse biological process such as the regulation of epithelial cell growth, immune function, the activation of tumor suppressor genes, and vision.

If you have a retinoid project that needs development and manufacturing, request a free project evaluation today.

Multi-kilo Retinoid Manufacturing Process

The chemists at Cedarburg Hauser Pharmaceuticals have developed and patented a unique process that produces multi-kilogram quantities of Fenretinide – a retinoid currently being developed to treat macular degeneration as well as a variety of different types of cancer.

John Cabaj and Jeff Hutchison, Senior Scientists at Cedarburg Hauser Pharmaceuticals, patented this process in 2008.  The full patent can be reviewed on the United States Patent and Trademark Office website by clicking on the listing below.

We have developed methods for handling and storing this light-sensitive compound on large scale, and have the expertise to make related retinoids for research or clinical trials.

“Preparation of Amides of Retinoic Acid via Mixed Anhydride and Mixed Carbonate Intermediates.”  Cabaj, Hutchison U. S. Patent 7,321,064, (January 2008)

Abstract
Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.

View complete patent

Retinoid Synthesis Expertise

In addition to the example demonstrated above, our chemists have also carried out the synthesis of Acitretin, a retinoid used to treat psoriasis. Cedarburg Hauser Pharmaceuticals is an experienced, contract development and manufacturing company that can help you both design and develop scalable chemistry for the synthesis of your retinoid-based drug or drug candidate.  Our experience in process validation, scale-up and manufacturing allows us to carry our process into kilogram and ultimately commercial scale production.

Cedarburg Hauser Pharmaceuticals as your contract research organization and pharmaceutical services resource

Process development & scale-up services

Our process development chemists will ensure your active pharmaceutical ingredient (API) can be successfully scaled up to the quantities you require for toxicity trials, clinical trials and even into commercialization.

Analytical method development services

We offer you a comprehensive suite of analytical services to ensure your active pharmaceutical ingredient has the levels of purity and stability you require throughout the various stages of your drug development project.

CMC & regulatory services

Our regulatory systems have met the rigors and challenges of clinical trials and marketed drugs in several countries.  If you need assistance with preparing and submitting your CMC filings or FDA filings, we have the knowledge and experience it takes to efficiently guide you through the complexities of the submission process.

Cedarburg Hauser Pharmaceuticals as your contract manufacturing organization

We have the flexibility to assist you with your GMP and/or non-GMP manufacturing needs for your active pharmaceutical ingredient (API) or pharmaceutical intermediate requirements.  You can realize several benefits.

• Leverage our experience and proven manufacturing techniques
• There is no need to purchase or rent costly production facilities and equipment
• We will acquire and manage all the raw materials required for the project at excellent prices

Tell us about your project

If you need a company that has experience and proven success in the area of retinoid synthesis, development and manufacturing, you can feel confident in choosing Cedarburg Hauser Pharmaceuticals. We want to learn more about your project and explore how we can use our experience and expertise in retinoid synthesis and manufacturing to help you achieve the successful outcome you are looking for.

Contact us today by submitting a request for more information form, a request for quote form, or calling one of our experienced project managers at (262) 376-1467.