CASE STUDY:
Enhancement and Isolation Process Development of a Natural Product

Cedarburg Hauser Pharmaceuticals was contracted to develop a scalable process for the isolation of a naturally occurring target molecule, a potential therapeutic for the treatment of Alzheimer’s disease. The natural abundance of the target compound in the biomass extract was less than 0.05% and the existing mg scale route required several chromatography steps requiring semi-preparative HPLC columns.

Cedarburg Hauser was able not only to develop an isolation process scalable to kilogram quantities of the target compound, but also developed methodology to enhance the compound of interest by 7-fold from a precursor compound already present in the natural source.